Reproductive Toxicology

Reproductive toxicity is a hazard related with some chemical substances, that they will affect in some way with usual reproduction; such materials are called reprotoxic. It comprises adverse properties on sexual role and fertility in mature males and women, as well as developmental toxicity in the offspring. It is normal to take a practical meaning, including a number of different properties which are unconnected to each other excepting in their consequence of lowered effective fertility. The Worldwide Harmonized System of Organization and Labeling of Chemicals (GHS) separates reproductive harmfulness from germ cell mutagenicity and carcinogenicity, even still both these hazards may also affect fertility. Some well-known group of substances which are poisonous for reproduction are teratogens – constituents which cause birth deficiencies – of which(S)-thalidomide is possibly the most infamous. Another group of constituents which has conventional much attention (and some controversy) as possibly toxic for reproduction are the so-called endocrine disruptors. Though, many constituents which are toxic for reproduction do not fall into any of these groups: lead compounds, for sample, are careful to be toxic for reproduction assumed their opposing effects on the normal intelligent and psychomotor growth of human babies and children. Development of the fertilized ovum

 

  • Nourishment within the genital tract
  • Implantation, Embryogenesis and Intrauterine growth
  • Placentation and placental function
  • Adverse reproductive effects in males and females
  • FDA Pregnancy Risk categories
  • Toxic effects on male and female reproduction

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