Day 1 :
Keynote Forum
Jessica Sember
University of Pennsylvania, USA
Keynote: Evening Induction of Labor Trial
Biography:
Jessica Sember completed her BSN in 2007, at the age of 22 from Mansfield University of Pennsylvania (USA). She is furthering her education with American Sentinel University of Colorado (USA), planning to obtain an MSN with a specialization of Leadership and Organizational Development. Jessica’s nursing career has always been in women’s health, but she has held various roles in labor and delivery, lactation consultant and currently as the perinatal education coordinator, where she facilitates childbirth classes for her health system. Jessica has worked on research projects and has spoken at 2 conferences in the past about breastfeeding.
Abstract:
The Childbirth Center at Geisinger Medical Center in Danville, PA is a busy unit with 1864 births in 2016. Most women labor and delivery spontaneously, but for some an induction of labor is required for either a medical indication or because they are past their due dates. Between July-December 2016, 79% of our 91 inductions of labor were delayed. The average length of time from admission until the start of the induction was 217 minutes. The purpose of the process improvement project is to develop a best practice process to increase patient and family satisfaction. This project is being piloted on 1 unit with the potential to effect 6 hospitals within the Geisinger Health System. During the months of February and March 2017, inductions of labor will be scheduled to arrive at 7 pm instead of 7 am. Results will be presented with monthly data reports to show time improvement during the trial. The data will compare the percentage of inductions of labor that were delayed before the evening induction trial with the percentage of delayed inductions of labor during the evening trial. The goals of this project are to improve the experience of the patient and their families by decreasing the incidence of delayed inductions of labor as well as decreasing the time from admission to the start of the induction. Changing the time of admission for inductions of labor help to better utilize all staff members including obstetrics, pediatrics, and nursing; optimizing safety for the patients.
Keynote Forum
Xunbin Huang
Huazhong University of Science and Technology, China
Keynote: Joint assessment of inhibin B, follicle stimulating hormone and luteinizing hormone can predict sperm retrieval in fine needle aspiration for 306 patients with non-obstructive azoospermia
Biography:
Xunbin Huang was educated at the Medical College of Wuhan University (China), Tongji Medical College,Huazhong University of Science and Technology (China). His education has a background in clinical medicine, reproductive medicine and Andrology.
Abstract:
Non-invasive laboratory tests that can predict sperm recovery in patients with non-obstructive azoospermia (NOA) has aroused an increasing interest toandrologists in recent years. The aim of this study was to evaluate the predictive value of sperm retrieval performed by FNA in NOA.
We conducted a retrospective study that 306 patients with NOA were performed with the fine needle aspiration (FNA) procedure at the clinic of the Centre for Reproductive Medicine,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Inhibin B, FSH and LH plasma levels were analyzed and 67 out of 306 cases has successfully retrieved sperm with FNA. Depending on the result of FNA procedure, we classified the whole NOA patients into two groups, successfully retrieved sperm group (SRS) and unsuccessfully retrieved sperm group (USRS).There were statistically signiï¬cant differences between them in terms of mean serum Inhibin B, FSH and LH levels. The areas under the curve (AUC) of inhibin B, FSH and LH were 0.696, 0.729 and 0.747 respectively, and the AUC for the joint assessment of the three hormones is 0.832. The cut-off points were 27.31 pg/ml, 11.68IU/L and 4.04IU/L for inhibin B, FSH and LH respectively. This study suggests that the joint assessment of inhibin B, FSH and LH is a more effective predictor for successful sperm retrieval in patients with NOA before decision making of an invasive procedure than any single hormonal factors
- Maternal and Perinatal Health
Regenerative Medicine
Women Reproductive Cancers
Infertility
Reproductive technology
Sexual and Reproductive Health and Rights
Location: London
Session Introduction
Hilde Masvie Ydstebo
Bærum Municipality, Norway
Title: The role of Tamang mothers-in law in promoting breastfeeding in Makwanpur District, Nepal
Biography:
Hilde Masvie Ydstebø completed her MSc in Mother and Child Health at International Perinatal Care Unit, Institute of Child Health, University College London in 2001. She is both a Public Health Nurse and a Psychiatric Nurse. She has been involved in health work both in rural Ethiopia for 11 years and in rural Tanzania for 3 years and is now working with migration health among refugees in Norway.
Abstract:
A qualitative study was conducted with the aim to explore the perinatal roles of Tamang mothers-in law in Nepal. 31 mothers-in laws were involved through semi-structured interviews and focus group discussion during May to July 2001. The data analyse showed that the mothers-in law saw themselves as key providers and decision makers in perinatal care practices. They held colostrum in high regard, used no pre-lacteals and supported early initiation of breastfeeding. This was in contrast to widespread reports from the area. Traditional patterns of promotive and preventive care were recognised. However, the sequences of newborn care identified highlighted practices that may increase the risk of hypothermia and infection. These directly relate to practices around bathing and wrapping. Twin themes of protection and provision runs through the data and may counterpoint the concepts of prevention and promotion that underpin allopathic health care.
Dr Indu Lata
Sanjay Gandhi Postgraduate Institute of Medical Sciences, India
Title: To study the prevalence and severity of depression in infertile females attending tertiary hospital in North India
Biography:
Dr Indu Lata had done her M.B.B.S. in 2001 and postgraduate MD (2005) in Obstetrics and Gynaecology from prestigious King Georges Medical University ,Lucknow, UP, India . Her areas of Interest are High risk Pregnancy, Infertility, Reproductive Endocrinology and Medicine. Presently she is working as Additional Professor and Consultant at Department of Maternal and Reproductive Health at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India. She has more than 25 publications in national and International journals. She is also part of editorial board of reputed journals.
Abstract:
Background
Many studies have been done on mental health of an infertile couple. The most common mental health problem in women with infertility is depression even in developed countries.
Depression is said to be a major problem associated with infertility especially in North India where children are highly valued to continue the name of a family for decades. Previous research has found that there are several factors including the age, education, social pressure and the pressure of husband’s family affects the infertile couples’ mental health. Infertility not only causes psychological pressure on the couple; but also develops physical and emotional instability. In developing country like India the women are generally blamed for the couple’s infertility. It adversely affects the married and social of life of the couple. It may also leads to abusing and domestic violence and ends into divorce. Being a mother is the only way for women to enhance their status within their family and community. In society the infertile women is segregated and neglected. The infertile women are often excluded from social events and ceremonies considered as inauspicious.The aim of the this study was to determine the prevalence and severity of depression among North Indian infertile women in relation to duration of infertility and other socio-demographic characteristics at a tertiary care center.
Material and Methods
This study was cross sectional study conducted from April 2014 to December 2016 at department of Maternal and Reproductive Health. We included 102 women with infertility attending our OPD for treatment in this study. After informed consent from participants the study and the questionnaire was explained in their local language. Data collection was done by a preset questionnaire. For this study primary Infertility was defined as the inability to achieve conception despite unprotected sexual intercourse of at least 1 year and secondary infertility, if the conception failed to occur after a previous pregnancy irrespective of the pregnancy outcome in the women despite unprotected sexual intercourse of at least one year.
Socio-demographic information including age, duration of infertility, educational level, occupation, monthly income, primary or secondary infertility was also obtained. Data was obtained using the Beck Depression Inventories (BDII). The classification of depression scores involves: 0–13 (Minimal range),14–19 (mild depression), 20–28 (moderate depression) and 29–63 (severe depression).
Results
Majority of the women 38.2.0% (39/102) were within 26-30 years age group followed by 31-35 year group (32.3%). Only 14.7% of the women were employed and maximum of them (85.2%) were housewives. Maximum women (41.1%) were postgraduate followed by graduated (35.2%) study subjects. With respect to income levels maximum were in middle income group (55.8%).In our study group maximum women (47%) had married life of upto 5 years and majority had infertility duration of upto 5 years (82.3%). Maximum women had secondary infertility (61.7%). The 41.1% (42/102) women had minimal range depressive symptoms, 17.6% (18/102) had mild depression, 32.3% (33/102) had moderate depression and 8.82% (9/102) had severe depression.
Discussion
The prevalence of depression due to infertility in females is quiet high in North Indian population. It needs identification and proper timely interventions to manage it besides the clinical management of infertility. As the treatment pathway itself is quiet long, costly and time taken. We advocate parallel psycho- behavioral interventions of entire family with clinical management of infertility.
Elkhoudri Noureddine
Higher Institute of Health Sciences University, Morocco
Title: Self-reported postpartum morbidity: Prevalence and determinants among women in Marrakesh, Morocco
Biography:
Elkhoudri Noureddine has completed his PhD from Cadi Ayyad University, valedictorian, and he is Assistant Professor at Higher Institute of Health Sciences University Hassan first Settat-Morocco. Healthcare professional has worked in several hospitals (mother-child hospital, University Hospital...) For more than 16 years
He has published more than 8 papers in reputed journals and has been serving as an editorial board member of some journals.
Abstract:
Maternal mortality is a public health problem particularly in developing countries. This is mainly related to maternal morbidity, especially during the post-partum period (Haemorrhage, infections…). In Morocco, little is known about maternal morbidity within the population. The aim of this study is to determine the prevalence of self-reported postpartum morbidity and grasp its determinants.
This descriptive and analytic cross-sectional survey was carried out in six health centers drawn randomly in Marrakesh, Morocco. A total of 1,029 women of reproductive age (15–49) giving birth in the year preceding the survey were enrolled. Women were examined in these health centers during the study period.
A questionnaire gathered information about socio-demographic, health and reported postpartum morbidity. Bivariate and multiple analyses were used to identify associated factors with the self-reported postpartum morbidity. Statistical significance was set at p < 0.05.
Self-reported postpartum morbidity prevalence was 13.1 % while haemorrhage, pregnancy-induced hypertension and fever were the main complications: 71.92 %; 12.18 % and 10.64 % respectively. According to the multiple logistic regression model, the illiteracy among women and the number of pregnancies greater than 3 determine independently this morbidity (OR = 1.24; CI 95 %: 1.09–1.54; and OR = 1.69; CI 95 %:1.04–2.70 respectively).
Reducing female illiteracy and fertility will help the fight against postpartum maternal morbidity, which is critical to the wellbeing of women and their infants.
Tanvi Tuteja,
K.J Somaiya Medical College and Hospital, India
Title: Tuberculosis and female reproductive health
Biography:
Biography: She is a practising obstetrician and gynaecologist at Mumbai, India. She is an Assistant professor at K.J somaiya Medical College and Hospital. Done her fellowship in Reproductive endocrinology and Robotics at St Mary;s hospital, Seoul, South Korea. Has many international and research publications as well as chapters in renowned books to her credit and is also has been a reviewer for journals of repute.
Abstract:
Tuberculosis (TB) is an important cause of mortality and morbidity all over the world and is particularly relevant in developing countries like India where the disease is endemic. Female reproductive system is very vulnerable to this infection and clinical presentation of this disease in a large majority of patients could be completely silent. This disease is an important cause of infertility, menstrual irregularity, pregnancy loss, morbidity to both the mother and child increases in pregnancy. The clinical diagnosis of genital TB requires a high index of suspicion. Approximately 50% of patients might have had tuberculous pleurisy, peritonitis, or renal, osseous, or pulmonary TB. A history of primary infertility in a woman in whom examination reveals no apparent cause and who gives a family history of TB should arouse suspicion .A history of poor general health associated with weight loss, undue fatigue, low-grade fever, or vague lower abdominal discomfort is often elicited in patients The diagnosis of TB is based on the identification of M. tuberculosis or others of the M. tuberculosis complex in culture. Other tests include Complete blood count, Chest radiographs,Tuberculin test, Menstrual blood for culture, Endometrial curettage-histologic examination, Hysterosalpingography, Ultrasonography etc . Treatment includes a 6-month regimen consisting of isoniazid (INH), rifampin (RIF) and pyrazinamide (PZA) for 2 months, followed by INH and RIF for 4 months. It is a global health priority that tuberculosis treatment be made available to women, particularly to those in low-income countries who are bearing the brunt of this epidemic.
Abdusemed Mussa Ali,
Walden University School of Health Science, Ethiopia
Title: Risky Sexual Behavior and Factors Associated with it among Public and Private Secondary School Students in Addis Ababa: a Cross-Sectional Comparative Study
Biography:
Abdusemed Mussa has a BA degree in Sociology and Masters in Public Health (MPH). He is currently a PhD fellow at Walden University School of Health Science studying Public Health with concentration in Community Health. Abdusemed has been working with Pathfinder International–Ethiopia Office at different capacities. He has over 10 years’ experience in implementing public health programs in Ethiopia. In his current role Abdusemed is assigned as a Knowledge Management Officer and is involved in the ongoing gathering of qualitative information, success stories, case studies, lessons learnt and other relevant information, ensuring that they are appropriately packaged, stored, shared with relevant stakeholders. Before moving to his current position, he served as a Communication Officer and has been actively involved in family planning advocacy. He is a member of the Ethiopian Public Health Association (EPHA).
Abstract:
Introduction: The contribution of the school type towards developing risky sexual behaviour by the students has not been explored well. Thus, this study tried to compare Risky Sexual Behavior and Factors Associated among Public and Private Secondary School Students in Addis Ababa, Ethiopia
Objective: To assess the prevalence of risky sexual behavior and factors associated with it among public and private secondary school students in Addis Ababa.
Method and material: A comparative cross sectional study was conducted from February15- Mar.16, 2015.A multistage random sampling technique was used to identify secondary schools. Study participants were selected using simple random sampling technique. Two population proportion formula was used to calculate a total sample size of 1037 students (517 public 518 private). Data was summarized using descriptive statistics including mean, proportion and standard deviation and inferential statistics such as chi-square test and binomial logistic regression. Ethical clearance was obtained from Debre Markos University.
Result: A total of 1,037 students (519 public and 518 private) participated in the study making the response rate 98.8%.Among all the students (public and private), a quarter of them (264(25.5%)) had started sexual intercourse at the mean age of 16.39years (+SD 1.7). Of those who stared sex, 188 (71.2%) of them reported risky sexual practices. The prevalence of risky sexual behaviour in public and private schools were 73.28 % and 69.17%, respectively. The difference between the two categories is not statistically significant (p>0.05).
Robera Olana Fite
Woliata Sodo University, Ethiopia
Title: Predictors of Therapeutic Communication between Nurses and Admitted Patients at Jimma University Specialized Hospital, Jimma Zone, Ethiopia
Biography:
Robera Olana has completed his Bsc Degree in Nursing at the age of 22 from Mizan Tepi University in 2013 and Msc Degree in Adult Health Nursing at the age of 26 from Jimma University in 2016. He is a lecturer in Woliata Sodo University. He is also serving as a coordinator of Post-Basic Nursing program. He has published one paper and there are three researches under review for publication (in Plos one, in BMC Hematology and Dove Medical Press). He has a passion in creating a safe living environment for human beings. He performed a research which is first of its type in Ethiopia concerning therapeutic communication.
Abstract:
Abstract
Background: Therapeutic communication is a purposeful interaction between health professionals and patients. There is a pressing need for research that focuses on factors influencing it. However, little is known about it. Therefore, this study was aimed at identifying predictors of therapeutic communication between nurses and admitted patients at Jimma University Specialized Hospital, Jimma zone, Ethiopia, 2016.
Methods: Institution based cross-sectional study was conducted at the Jimma University Specialized Hospital from March 21 to April 9, 2016. 192 study participants recruited using stratified sampling technique.. Interviewer administered questionnaire was employed as the data-collection tool Principal component analysis, Independent t-test, one-way ANOVA, simple and multivariable linear regressions were applied using a statistical package for Social Sciences (SPSS) version20.A P-value less than 0.05 were taken as significant association.
Result: 192 admitted patients at the Jimma University Specialized Hospital participated in the study, obtaining a response rate of 96%. The study revealed that 67(34.9%) of the patients rated high level of therapeutic communication. Significant predictors of therapeutic communication were educational status (β=5.870, P=0.011), language difference (β= -6.002, P=0.014), education difference (β=5.208, P=0.010) and Perceived patient view score (β=3.573,PË‚0.001)
Radhouane Achour,
Emergency Department of Maternity and Neonatology Center, Tunisia
Title: Congenital cervical atresia : Fertility prognosis
Biography:
ACHOUR Radhouane is associate professor at faculty of medicine of Tunis-Tunisia; He has published many basic and clinical articles in relation to gynecology and obstetrics. , his research interests include Rare Diseases in gynecology and prenatal diagnosis.
He serves as associate professor, Emergency Department of Gynecology and Obstetrics in maternity and neonatology center Tunis Tunisia.
He also serves as member of the editorial team Asian Pacific Journal of Reproduction , as member of the editorial team of the Global Journal of Rare Diseases ; member of the editorial team of the Journal of Neonatal Biology and member of The Science Advisory Board.
Abstract:
Congenital cervical atresia and hypoplasia are rare abnormalities caused by abnormal development of Mullerian system, they may arise as a result of abnormal fusion of the mullerian ducts with the urogenital sinus, imperfect canalization of the lower mullerian system, or segmental atrophy of a normally formed mullerian system.
Congenital cervical atresia and hypoplasia generally require reconstruction or disobjection of the outflow tract.
Infertility is a common complication, and only four previous pregnancies have been reported.
We report a case of a congenital cervical atresia diagnosed at the age of 28 years. Aged 32 years was referred to our unit and had a successful pregnancy after in vitro fertilization.
After an appropriate case-by-case assessment, we believe that a successful pregnancy outcome can be achieved in women with congenital cervical abnormalities.
Khalimova Fariza Tursunbaevna,
Tajik State Medical University, Tajikistan
Title: Characteristic of humoral autoimmunitette in women different ethnic groups
Biography:
Khalimova Fariza Tursunbaevna. Head of the Department of Normal Physiology of the Tajik State medical University named after Abuali ibn Sino. In 1988 she graduated from this university. The topic of the doctor's "Reproductive health of women of fertile age: Population-cluster analysis" , Russia. In 2009 PhD in Medical Science, Russia on the theme "Ecological-physiological and ethnic features of adaptive reactions of the organism of the alien population of the agro-industrial region of Russia".
Passed refresher courses: Evidence-based medicine and the basics of scientific research; Improvement of teaching skills in the Swiss Agency for Development and Cooperation; Theoretical and practical aspects of the development of modern medical science; Improvements in teaching skills; Actual problems of public health and health management; Modern physiology and new instrumental methods of research; Management and economics of health; Organization of treatment and prophylactic help to the population. Published more than 85 scientific papers on reproductive health of women.
Abstract:
We studied the changes in B-lymphocyte and serum immunoglobulin G (IgG), A (IgA) and M (IgM) in women of different ethnic groups, taking into account the climatic and geographic conditions of living. The average regional norms of the above indices in the peripheral blood of women of the Russian Federation and Tajikistan have been established. Studies have shown that in Tajik women, the average regional B-lymphocyte counts (CD19 +) and IgG immunoglobulin were higher, and the IgA immunoglobulin values were lower, IgM indices did not differ. It has been established that positive predictions of B-lymphocytes, IgG immunoglobulin from their mean regional values and negative deviation of IgA immunoglobulin should be considered as prognostic criteria for forming a risk group of reproductive disorders in Russian and Tajik women.
In order to objectively evaluate the results obtained in the study of the influence of ethnic and climatic-geographical factors on the status of the immune status of the women being examined, we determined the average regional standards for the indices of autoimmune factors of humoral immunity. As studies have shown, the average regional values of B-lymphocytes and serum immunoglobulins of Russian women differed from those of women in Tajikistan. For example, in Tajik women, the average regional B-lymphocyte count (CD19 +) was 51.6% higher. At the same time, immunoglobulin IgA values ​​were lower by 40.0%, IgG higher by 18.0%, IgM values ​​differed insignificantly, statistically unreliable. Taking into account this circumstance, the analysis of the obtained data was carried out and the specific weight of the examined women, the values ​​of the immunological indices, which had reliable statistical differences with the average regional norms obtained during the study, was determined. In comparison with the average regional norm, in 30% of Russian women (risk group No. 1), the number of B-lymphocytes (CD19 +) was 42.3% higher, IgA 62.5% lower, IgG 62.5% higher, IgM The regional average. In 70.0% of the surveyed indicators were not statistically different from the average regional rate. In comparison with the average regional norm in 50.0% of Tajik women (risk group No. 2), the number of B-lymphocytes (CD19 +) was higher by 24.3%, IgA lower by 38.4%, IgG higher by 15.8% IgM corresponded to the regional average. In 50.0% of the surveyed indicators were not statistically different from the average regional rate.As a result of a complex comparative physiological study, among women of different ethnic groups living in different climatic and geographic territories, it was found that in Tajik women the average regional B-lymphocyte counts (CD19 +) and IgG immunoglobulin were higher, and IgA IgG values were lower, IgM values differed slightly , Is statistically unreliable. It has been established that the indicators of humoral autoimmunity with a positive deviation from their average regional B-lymphocyte values, IgG immunoglobulin and negative IgA immunoglobulin deviation should be considered as prognostic criteria for forming a risk group of reproductive disorders in Russian and Tajik women.
We studied the changes in B-lymphocyte and serum immunoglobulin G (IgG), A (IgA) and M (IgM) in women of different ethnic groups, taking into account the climatic and geographic conditions of living. The average regional norms of the above indices in the peripheral blood of women of the Russian Federation and Tajikistan have been established. Studies have shown that in Tajik women, the average regional B-lymphocyte counts (CD19 +) and IgG immunoglobulin were higher, and the IgA immunoglobulin values were lower, IgM indices did not differ. It has been established that positive predictions of B-lymphocytes, IgG immunoglobulin from their mean regional values and negative deviation of IgA immunoglobulin should be considered as prognostic criteria for forming a risk group of reproductive disorders in Russian and Tajik women.
In order to objectively evaluate the results obtained in the study of the influence of ethnic and climatic-geographical factors on the status of the immune status of the women being examined, we determined the average regional standards for the indices of autoimmune factors of humoral immunity. As studies have shown, the average regional values of B-lymphocytes and serum immunoglobulins of Russian women differed from those of women in Tajikistan. For example, in Tajik women, the average regional B-lymphocyte count (CD19 +) was 51.6% higher. At the same time, immunoglobulin IgA values ​​were lower by 40.0%, IgG higher by 18.0%, IgM values ​​differed insignificantly, statistically unreliable. Taking into account this circumstance, the analysis of the obtained data was carried out and the specific weight of the examined women, the values ​​of the immunological indices, which had reliable statistical differences with the average regional norms obtained during the study, was determined. In comparison with the average regional norm, in 30% of Russian women (risk group No. 1), the number of B-lymphocytes (CD19 +) was 42.3% higher, IgA 62.5% lower, IgG 62.5% higher, IgM The regional average. In 70.0% of the surveyed indicators were not statistically different from the average regional rate. In comparison with the average regional norm in 50.0% of Tajik women (risk group No. 2), the number of B-lymphocytes (CD19 +) was higher by 24.3%, IgA lower by 38.4%, IgG higher by 15.8% IgM corresponded to the regional average. In 50.0% of the surveyed indicators were not statistically different from the average regional rate.As a result of a complex comparative physiological study, among women of different ethnic groups living in different climatic and geographic territories, it was found that in Tajik women the average regional B-lymphocyte counts (CD19 +) and IgG immunoglobulin were higher, and IgA IgG values were lower, IgM values differed slightly , Is statistically unreliable. It has been established that the indicators of humoral autoimmunity with a positive deviation from their average regional B-lymphocyte values, IgG immunoglobulin and negative IgA immunoglobulin deviation should be considered as prognostic criteria for forming a risk group of reproductive disorders in Russian and Tajik women.
Nirav R.Soni,
A-One Pharmacy College, India
Title: Bioanalytical method development and validation of metaxalone in human plasma by LC-MS/MS
Biography:
Nirav has completed his M.Pharm at the age of 23 years from Gujarat Technological University (GTU) and he has taken Post-Graduate Diploma Intellectual Property Rights (PGDIPR). He is the Ass.professor in A-One Pharmacy College, India. He got “Best Teaching Award” and he has achieved award of “Best-Student of the year” for the year 2013. He has published research , review articles and letter to the editors in reputed journals. He has been serving as an editorial board member as well as reviewers of repute. Recently, He got "National Award"- PEARL Foundation “Best Assistant Professor Award in
Abstract:
Abstract:-A simple, rapid, sensitive, and selective liquid chromatography-tandem mass spectrometry (MS) method was developed and validated for the quantification of Metaxalone, a skeletal muscle relaxant, in human plasma using Metaxalone –D6 as Internal Standard (IS). Following Liquid-Liquid Extraction (LLE) , the analytes were separated using an isocratic mobile phase on a reverse phase C18 column (Chromatopak peerless basic 50× 4.6mm× 3.0µm ) and analyzed by MS in the multiple reaction monitoring mode using the respective [M+H]+ ions, m/z 222.14 / 160.98 for Metaxalone and m/z 228.25 /167.02 for the IS. The assay exhibited a linear dynamic range of 25.19 - 2521.313 ng/mL for metaxalone in human plasma. The goodness of fit was consistently greater than 0.98 during the course of validation. The range of accuracy and precision of the back-calculated concentrations of the standard curve points was from 94.1 % to 104.4 % and 0.3 % to 5.6 % for metaxalone A run time of 2.0 min for each sample and injection volume is 5 µl. The validated method has been successfully used to analyze human plasma samples for application in pharmacokinetic, bioavailability and bioequivalence (BA-BE) studies.
Biography:
Katie graduated from Manchester Medical School in 2013, and then worked as a foundation doctor in Manchester for 2 years. During this time she completed the DRCOG and FSRH diplomas. She then worked in sexual health for 1 year, completing contraceptive implant and IUD training. She is now completing academic GP training.
This research has also been presented at the Faculty of reproductive health conference in 2016 and at the royal college of GP conference in 2016
Abstract:
Introduction
England has one of the highest teenage pregnancy rates in Europe. Although there is a wide selection of available contraceptives, they must be used consistently and correctly to prevent pregnancy.
There is limited data on contraception continuation rates in teenagers in the UK.
This audit aims to establish baseline continuation rates of the contraceptive pill/injection in <18’s within a sexual health service.
Method
A retrospective audit on all 305 <18’s started on the contraceptive pill/injection between Jan-March 2014. Continuation rates at 6 and 12 months were compared to the 2002 National Survey of Family Growth in the United States, standards cited by FSRH guidance.
Results
The continuation rates of the combined oral contraceptive pill (COC) at 6 and 12 months were 59% and 44.9% respectively, the progesterone only pill (POP) were 37.3% and 23.6% respectively and the injection were 60% and 22.9% respectively.
conclusion
The continuation rates were lower than the standard when compared to women of all ages. However, using age-adjusted rates, the COC continuation rate exceeded the standard by 3%, and the POP and injection rates were closer to the standard.
The COC had the highest continuation rate, suggesting the COC should be the method of choice in <18’s.
Continuation rates dropped off more sharply in the first 6 months, suggesting this is the crucial time to remind, educate and engage with teenagers.
Continuation rates were higher in the section of the service with a dedicated vulnerable young persons’ worker.